Porencephaly and optic hypoplasia in neonatal isoimmune thrombocytopenia.
نویسندگان
چکیده
Five children with prenatal intracerebral damage associated with neonatal isoimmune thrombocytopenic purpura are described, and characteristic neurological features listed. These include optic hypoplasia which has not been previously documented in this condition.
منابع مشابه
Neonatal Alloimmune Thrombocytopenic Purpura and Congenital Porencephaly in Two Siblings Associated With a “New” Maternal Antiplatelet Antibody
We report a brother and sister. both of whom have porencephaly. hydrocephalus. optic atrophy. severe mental retardation. and spastic quadraparesis. In the younger child. abnormal intracranial structure was demonstrated by sonography at 32 weeks’ gestation and was suspected earlier. Both children had transient severe thrombocytopenia as newborns. The mother is healthy and has never had purpura o...
متن کاملNeonatal Alloimmune Thrombocytopenic Purpura and Congenital Porencephaly in Two Siblings Associated With a “New” Maternal Antiplatelet Antibody
We report a brother and sister. both of whom have porencephaly. hydrocephalus. optic atrophy. severe mental retardation. and spastic quadraparesis. In the younger child. abnormal intracranial structure was demonstrated by sonography at 32 weeks’ gestation and was suspected earlier. Both children had transient severe thrombocytopenia as newborns. The mother is healthy and has never had purpura o...
متن کاملMaternal platelet antibody levels in neonatal isoimmune thrombocytopenia.
A case of neonatal isoimmune thrombocytopenia (NIT) is described in which maternal platelet antibody levels decreased during the course of pregnancy. It is suggested that if this disorder is clinically suspected, maternal serum should be assessed for anti-platelet specificity using immunoblot analysis.
متن کاملNeonatal alloimmune thrombocytopenic purpura and congenital porencephaly in two siblings associated with a "new" maternal antiplatelet antibody.
We report a brother and sister, both of whom have porencephaly, hydrocephalus, optic atrophy, severe mental retardation, and spastic quadriplegia. In the younger child, abnormal intracranial structure was demonstrated by sonography at 32 weeks' gestation and was suspected earlier. Both children had transient severe thrombocytopenia as newborns. The mother is healthy and has never had purpura or...
متن کاملNeonatal cholestasis and hypopituitarism 787 Neonatal cholestasis and hypopituitarism
Optic nerve hypoplasia with hypopituitarism and intact septum pellucidum is a variant of septo-optic dysplasia or deMorsier's syndrome.' Although neonatal jaundice has been seen with this syndrome, the association with severe prolonged cholestatic jaundice has not been emphasised. We describe three patients who presented with cholestatic jaundice and were found to have optic nerve hypoplasia an...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 64 6 شماره
صفحات -
تاریخ انتشار 1989